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. 2011 Aug 16;6(8):e23410. doi: 10.1371/journal.pone.0023410

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Yallowitz et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A–F) Serial sections through control (A, C, E) and Hox10 mutants (B, D, F) at E13.5. (A) Foxd1 expression is observed in the cortical stromal cells fully integrated into the periphery of the kidney at E13.5 in controls. (B) Foxd1 signal is regionally restricted in Hox10 mutants. (C–D) Expression of the nephrogenic marker Pax2 in control (C) and Hox10 mutant (D) embryos. In Hox10 mutants, Pax2 (D) is restricted to the domain in the kidney that is selectively expressing Foxd1. Red asterisks depict nephrogenic mesenchymal expression of Pax2 in (C, D). Similar patterns are observed with both Eya1(E, F) and Six2 (G,H) in which the normal expression in the mesenchymal condensations in the in the nephrogenic zone (E, G) becomes positionally restricted to regions of Foxd1-expressing cells in the Hox10 mutant (F, H).