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. 2011 Aug 16;6(8):e23410. doi: 10.1371/journal.pone.0023410

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Yallowitz et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) In control embryos, Foxd1 is expressed in the cortical stromal cells that surround the kidney at E15.5. (B) Foxd1 signal in Hox10 mutants is restricted peripherally in the developing kidney (arrowheads). (C–F) Pbx1 and Raldh2 are known markers for stromal cell differentiation that are normally expressed in the nephrogenic zone and cortical stroma of the developing kidney in control embryos (C, E). The expression of both of these genes is restricted (D, F arrowheads) in a pattern similar to what is observed for Foxd1 in Hox10 mutants (B). (G) Tenascin-C is expressed in differentiated cortical stromal cells in controls. (H) Tenascin-C expression is lost in the kidney periphery in Hox10 mutants (arrowheads). (I–J) Sfrp1 expression in control (I) and Hox10 mutant (J) E14.5 embryos. Sfrp1 is strongly expressed in the kidney capsule of control animals (J) and is missing in the periphery (arrowheads) of Hox10 mutant kidneys (J).