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. Author manuscript; available in PMC: 2012 Jul 15.
Published in final edited form as: Org Lett. 2011 Jun 21;13(14):3746–3749. doi: 10.1021/ol2014347

Table 1.

Optimization of the Transannulation Reaction of Triazole 1aa

graphic file with name nihms306091u2.jpg
no. catalyst (2.5 mol %) Lewis acid (5.0 mol %) solvent 0.06 M yieldb (%)
1 Rh2(OAc)4 AgOCOCF3 toluene NR
2 Rh2(pfb)4 AgOCOCF3 toluene NR
3 Rh2(dosp)4 Al(OTf)3 toluene 63
4 Rh2(oct)4 AgOCOCF3 toluene 53
5 Rh2(oct)4 AgOCOCF3 hexane 67
6 Rh2(oct)4 - hexane NRc
7 Rh2(oct)4 AgOTf hexane NR
8 Rh2(oct)4 CsF hexane NR
9 Rh2(oct)4 Zn(OTf)2 hexane NR
10 Rh2(oct)4 Y(OTf)3 hexane NR
11 Rh2(oct)4 AgOCOCF3 DCM NR
12 Rh2(oct)4 AgOCOCF3 DCE NR
13 Rh2(oct)4 AgOCOCF3 THF NR
14 Rh2(oct)4 CF3SO3H hexane Dec.d
15 Rh2(oct)4 CF3CO2H hexane Dec.
a

All reactions were performed at 70 °C for 12 h with 0.2 mmol of 1a and 0.3 mmol of alkyne;

b

Isolated yield;

c

NR = No Reaction;

d

Dec. = Decomposition.