Table 1.
The detected P. vivax proteins involved in parasite's metabolic pathways
| Gene ID | Enzyme | EC no.a | Reaction catalyzed |
|---|---|---|---|
| Glycolysis | |||
|
| |||
| PVX_095015 | Enolase | 4.2.1.11 | Glycerate-2P ↔ Phosphoenol-pyruvate |
| PVX_114445 | Pyruvate kinase | 2.7.1.40 | Phosphoenol-pyruvate + ADP ↔ Pyruvate + ATP |
| PVX_118495 | Triosephosphate isomerase | 5.3.1.1 | Glyceraldehyde-3P ↔ Glycerone-P |
| PVX_118255 | Fructose 1,6-bisphosphate aldolase | 4.1.2.13 | Aldolase ↔ Glyceraldehyde-3P |
| PVX_116630 | Lactate dehydrogenase | 1.1.1.27 | Pyruvate + NADH+H+↔Lactate + NAD+ |
|
| |||
|
Nucleic acid biosynthesis Purine salvage pathway | |||
|
| |||
| PVX_111245 | Adenosine deaminase | 3.5.4.4 | Adenosine + H2O ↔ Inosine + NH3 |
| PVX_092535 | Adenylate and Guanylate cyclase catalytic domain containing protein | 4.6.1.2 | GTP ↔ 3′,5′-cyclic GMP + PPi |
| PVX_094840 | Hypoxanthine phosphoribosyltransferase | 2.4.2.8 | Hypoxanthine + PRPP ↔ IMP + PPi |
|
| |||
| Pyrimidine metabolism | |||
|
| |||
| PVX_083135 | Aspartate carbamoyltransferase | 2.1.3.2 | L-Aspatate + Carmoyl-P ↔ N-carbamoyl-L-Aspartate + Pi |
|
| |||
| TCA cycle | |||
|
| |||
| PVX_084960 | ATP-specific succinyl-CoA synthetase beta subunit | 6.2.1.5 | ATP + Succinate + CoA ↔ ADP + Orthophosphate + Succinyl-CoA |
|
| |||
| Hemoglobin digestion | |||
|
| |||
| PVX_115000 | Falcilysin | 3.4.24.- | Acting on peptide bonds |
| PVX_097935 | Subtilisin-like protease precursor | 3.4.21.62 | Hydrolyzes peptide amides |
| PVX_086040 | Aspartic protease PM4 | 3.4.23.B14 | Cleavage of hemoglobin |
| PVX_122425 | M1-family aminopeptidase | 3.4.11.2 | Release of an N-terminal amino acid from a peptide |
Plasmodium metabolic pathways can be found at http://siteshujiacil/malaria.
a
Enzyme Commission (EC) numbers of P falciparum orthologs.