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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: J Invest Dermatol. 2011 May 26;131(9):1861–1868. doi: 10.1038/jid.2011.131

Figure 4. LC proliferation in mice that express a Wnt antagonist in epidermis.

Figure 4

(a) Epidermal sheets were prepared on postnatal day 7 (P7) from doxycycline-exposed littermate control (Cont) and K14-KRM1; K5-rtTA; tetO-Dkk1 (TT) mice, stained with anti-MHC class II mAb and anti-Ki67 pAb and visualized via immunofluorescence microscopy (bar = 50 μm). (b) LC proliferation indices as determined by dividing MHC class II+ Ki67+ cells by MHC class II+ cells (3 random fields per mouse, n=5, *p<0.01). Error bars represent the mean ± SEM. (c) Various stages of mitosis in MHC class II+ cells as depicted by Ki67 staining (bar = 15 μm).