Table 2.
Demographic and clinical characteristics of the 81 perinatally HIV-infected children with antiretroviral therapy interruption (TI) and available CD4 information.
| Characteristic | Total (N=81) |
|---|---|
| Sex, N (%) | |
| Male | 31 (38) |
| Female | 50 (62) |
| Birth Cohort, N (%) | |
| 1991-1993 | 33 (41) |
| 1994-1995 | 25 (31) |
| 1996-1997 | 13 (16) |
| 1998-2002 | 10 (12) |
| Race, N (%) | |
| Black | 59 (73) |
| Not Black | 15 (18) |
| Unknown | 7 (9) |
| Ethnicity, N (%) | |
| Hispanic | 19 (24) |
| Not Hispanic | 61 (75) |
| Unknown | 1 (1) |
| Age at ART initiation (years), Median (Q1, Q3) | 1.0 (0.4, 2.3) |
| Age at TI (years), Median (Q1, Q3) | 10.3 (6.8, 12.9) |
| CD4% at TI, Median (Q1, Q3) | 32.0 (25.3, 37.0) |
| Log HIV viral load at TI,1 Median (Q1, Q3) | 3.1 (2.6, 4.1) |
| CDC clinical category at TI, N (%) | |
| N/A/B | 58 (72) |
| C | 23 (28) |
| Nadir CD4% before TI,3 Median (Q1, Q3) | 21.0 (14.0, 27.0) |
| Difference between CD4% at TI and Lowest CD4% before TI, Median (Q1, Q3) | 10.0 (3.8, 15.0) |
| Peak Log HIV viral load before TI,4 Median (Q1, Q3) | 5.3 (4.5, 5.8) |
| Most recent regimen prior to TI, N (%) | |
| HAART | 50 (62) |
| PI-based HAART | 43 (53) |
| Non-PI-based HAART | 7 (9) |
| Non-HAART | 31 (38) |
| NRTI only – 3 drugs | 4 (5) |
| NRTI only – 1 or 2 drugs | 27 (33) |
| Ever use of HAART prior to TI?, N (%) | |
| Yes | 57 (70) |
| No | 24 (30) |
| Duration of most recent regimen prior to TI (months), Median (Q1, Q3) | 36.6 (12.7, 70.6) |
| # of regimens prior to TI, Median (Q1, Q3) | 3 (2, 6) |
| Calendar year of TI, N (%) | |
| 1996-2000 | 10 (12) |
| 2001-2005 | 39 (48) |
| 2006-2008 | 32 (40) |
1
N=63 with viral load information
2
N=14 with Nadir CD4=CD4 at TI
3
N=8 with Nadir CD4%=CD4% at TI
4
N=4 with Peak viral load=viral load at time of TI.