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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Thorac Cardiovasc Surg. 2011 Jul 2;142(3):554–562. doi: 10.1016/j.jtcvs.2010.10.061

Table 1.

Major and Minor Eligibility Criteria for Z4032 trial*

Major Criteria

  1. FEV1 ≤ 50% predicted

  2. DLCO ≤ 50% predicted

Minor Criteria

  1. Age ≥75

  2. FEV1 51–60% predicted

  3. DLCO 51–60% predicted

  4. Pulmonary hypertension (defined as a pulmonary artery systolic pressure greater than 40mmHg) as estimated by echocardiography or right heart catheterization

  5. Poor left ventricular function (defined as an ejection fraction of 40% or less)

  6. Resting or Exercise Arterial pO2 ≤ 55 mm Hg or SpO2 ≤ 88%

  7. pCO2 > 45 mm Hg

  8. Modified Medical Research Council (MMRC) Dyspnea Scale ≥ 3.

*

Eligible patients must have met either 1 Major or 2 Minor Criteria