Figure 2. VEGFR-2 phosphorylation in HEK293 cells and effect of non-synonymous variants.
The y axis corresponds to the ratio of phosphorylated VEGFR-2 to total VEGFR-2. Values are normalized to basal phosphorylation levels of reference sequence KDR. “−” refers to basal phosphorylation levels and “+” refers to VEGF-A165 stimulation. Wt = reference sequence cDNA. The mean ± SEM of 3 experiments in triplicate is shown.