Table 4.

Parameters that are used in the ECM model.

Parameter	Description	Value	Refs.
Diffusion coefficients (cm2 s−1)
$D_E^s$	EGF in surrounding tissue	5.18 × 10−7	(Thorne et al., 2004)
$D_E^d$	EGF in the duct	1.66 × 10−6	(Thorne et al., 2004)
$D_E^t$	EGF in tumor	1.0 × 10−7	this work
$D_T^s$	TGF-β in surrounding tissue	1.8 × 10−7	(Brown, 1999; Koka et al., 1995; Woodcock et al., 1993)
$D_T^d$	TGF-β in the duct	3.6 × 10−7	this work
$D_T^t$	TGF-β in tumor	1.0 × 10−7	this work
Production rates
$k_{i,f}^E$	production rate of EGF from fibroblasts	1 × 10−6–5 × 10−4 pg/(cell·h) (1.0d-6)	(Danielsen & Rofstad, 1998), this work
$k_{i,m}^E$	production rate of EGF from myofibroblasts	2.09 × 10−6 pg/(cell · h)	this work
$k_{i,t}^T$	production rate of TGF-β from TECs	3.86 × 10−5 pg/(cells · h)	(Wakefield et al., 1987), this work
decay rates
dE	EGF	3.6 × 10−3 h−1	(Kudlow et al., 1986), this work
dT	TGF-β	= dE	this work
Threshold values
thT	the threshold TGF-β value for activation of myofibroblasts	0.7567 nM	(Kunz-Schughart et al., 2003), this work