Diffusion coefficients (cm2 s−1) |
|
EGF in surrounding tissue |
5.18 × 10−7
|
(Thorne et al., 2004) |
|
EGF in the duct |
1.66 × 10−6
|
(Thorne et al., 2004) |
|
EGF in tumor |
1.0 × 10−7
|
this work |
|
TGF-β in surrounding tissue |
1.8 × 10−7
|
(Brown, 1999; Koka et al., 1995; Woodcock et al., 1993) |
|
TGF-β in the duct |
3.6 × 10−7
|
this work |
|
TGF-β in tumor |
1.0 × 10−7
|
this work |
Production rates |
|
production rate of EGF from fibroblasts |
1 × 10−6–5 × 10−4 pg/(cell·h) (1.0d-6) |
(Danielsen & Rofstad, 1998), this work |
|
production rate of EGF from myofibroblasts |
2.09 × 10−6 pg/(cell · h) |
this work |
|
production rate of TGF-β from TECs |
3.86 × 10−5 pg/(cells · h) |
(Wakefield et al., 1987), this work |
decay rates |
dE |
EGF |
3.6 × 10−3 h−1
|
(Kudlow et al., 1986), this work |
dT |
TGF-β
|
= dE
|
this work |
Threshold values |
thT |
the threshold TGF-β value for activation of myofibroblasts |
0.7567 nM
|
(Kunz-Schughart et al., 2003), this work |