Table II.

Promising associations between serum androgens and inflammation-related SNPs in 560 healthy men (FDR-adjusted q-value <0.1)

Androgen	dbSNP ID	Minor/Major Allele	MAF	Cytoband	Genomic position	SNP Function	Gene	Beta*	SE	Nominal P-value	FDR-adjusted q-value
T	rs893226	T/G	0.38	16q12.2	54060397	intergenic	MMP2	0.13	0.03	1.5×10−5	0.09
	rs3822356	C/T	0.24	5q31.3	140002620	intronic	CD14	0.15	0.03	1.7×10−5	0.09
Androstenedione	rs348373	T/C	0.11	19p13.3	6494342	intergenic	TNFSF9	0.16	0.03	4.9×10−6	0.05

MAF, minor allele frequency; 4-Androstene-3,17-dione; FDR, false discovery rate; SNP, single nucleotide polymorphism; T, total testosterone

^*adjusted for age (55–59, 60–64, 65–69, and 70–74); additive coding used for SNPs with minor allele as coded allele; beta is for natural log transformed serum sex hormones