Table III.

Gene-based FDR- q-values for serum androgens and the top inflammation genes in 560 healthy men (FDR-adjusted q-value < 0.1)^*

Gene Symbol	Cytoband	T	3αdiol G	Androstene-dione	Bioavailable T	SNPs Included in Gene-based Test
MMP2†	16q12.2	0.06	0.91	0.85	0.09	rs837531, rs1816595, rs12924764, rs11643163, rs7187242, rs11859163, rs893226, rs1005913, rs1347653, rs16955194, rs243866, rs17301608, rs1053605, rs9302671, rs243842, rs183112, rs1992116, rs243840, rs11639960, rs243834, rs1861320, rs8054459
CD14	5q31.3	0.06	0.80	0.99	0.09	rs778583, rs778584, rs7721577, rs2569188, rs2569193, rs12517200, rs3822356, rs753279, rs1583005
IK	5q31.3	0.06	0.80	0.99	0.09	rs2569188, rs2569193, rs12517200, rs3822356, rs753279, rs1583005, rs2286394
PRG2†	11q12	0.06	0.92	0.87	0.16	rs10400305, rs3741089, rs490358, rs10792094, rs555097, rs3851114, rs3741085, rs10792095

3αdiol G, 5α-androstane-3α, 17β-diol glucuronide; 4-Androstene-3,17-dione; FDR, false discovery rate; SNPs, single nucleotide polymorphisms; T, total testosterone

^*Global gene-based P-values generated across single nucleotide polymorphisms within 20kb upstream or 10kb downstream of the gene boundaries using an adaptive rank truncated product method with 40,000 bootstrap samples; P-values are for association with natural log-transformed androgens after adjustment for FDR using the method by Benjamini and Hochberg¹⁶

^†Gene-based P-values for these genes used 1 million bootstrap samples