Table 5.
Piecewise Weibull Model of Tuberculosis Risk After HAART Initiation
| Multivariate model adjusted for cohort |
||
| Relative hazard (95% CI) | P value | |
| Male sex2 | ||
| <3 months | 3.13 (.65–14.19) | .16 |
| ≥3 months | 0.78 (.51–1.17) | .23 |
| Race | ||
| Black—Canada | 13.51 (2.78–65.67) | .002 |
| Black—USA | 1.50 (.97–2.34) | .07 |
| Hispanic | 2.18 (1.30–3.66) | .003 |
| Other | 2.84 (1.30–6.18) | .009 |
| White | 1.0 | … |
| IDU | 1.60 (1.11–2.31) | .01 |
| Antiretroviral therapy naive (yes vs no) | 1.33 (.94–1.88) | .10 |
| CD4 | ||
| 0<CD4≤50 | 1.94 (1.14–3.29) | .02 |
| 50<CD4≤100 | 2.37 (1.34–4.18) | .003 |
| 100<CD4≤200 | 1.91 (1.18–3.08) | .008 |
| CD4 >200 | 1.0 | … |
| log10(HIV RNA)1,2 | ||
| <3 months | 1.93 (1.39–2.69) | <.001 |
| ≥3 months | 0.99 (.80–1.23) | .92 |
NOTE. Tuberculosis risk is dichotomized according to <3 months versus ≥ 3 months after HAART initiation. Shape parameter: <3 months shape = 1.33, ≥3 months space = 0.92. This analysis includes imputed values for missing data. CI, confidence interval; HAART, highly active antiretroviral therapy; IDU, injection drug use as HIV risk factor.
1
Value prior to HAART initiation. Multiple imputation was used for missing values for CD4 and HIV RNA.
2
Interaction with time after HAART initiation: male sex P value = .09; log10 HIV-1 RNA P value < .001.