Table 2.

Performance of FibroSure, APRI, and CXCL10 for Detection of Liver Fibrosis on the Second Biopsy

	Sensitivity	Specificity	PPV	NPV	AUROC (SE)
Significant fibrosis (≥3)
FibroSure > 0.48	61.9	70.3	32.5	88.9	0.746 (0.0657)
APRI >1.5	13.6	94.6	37.5	82.2	0.694 (0.0673)
ln(CXCL10) > 6.75	45.5	80.6	35.7	86.2	0.7 (0.067)
Insignificant fibrosis (≤2)
FibroSure < 0.31	51.6	81	92.2	27.9
APRI < 0.5	61.3	68.2	89.1	29.4
ln(CXCL10) ≤ 5.86	30.1	95.5	96.6	24

NOTE. Fibrosis assessed using the Ishak fibrosis index. APRI, aspartate aminotransferase to platelet ratio; AUROC, area under the receiver operating curve; CXCL10, interferon [IFN] γ−inducible protein 10 [IP-10]; NPV, negative predictive value; PPV, positive predictive value; SE, standard error.