Table 2.

Solicited Local and Systemic Adverse Effects During the Week After Vaccination

	Vaccinated subjects, %
Effect	First vaccination, 25 μg (n = 60)	First vaccination, 49 μg (n = 60)	Second vaccination, 25 μg (n = 49)	Second vaccination, 49 μg (n = 54)
Local reactions1
Pain at injection site
None	75	65	80	63
Mild	23	35	20	35
Moderate	2	0	0	2
Tenderness
None	57	38	47	31
Mild	40	60	53	69
Moderate	3	2	0	0
Erythema
None	92	87	96	94
<20 mm	8	10	4	4
≥20 and <50 mm	0	3	0	2
Swelling/induration
None	93	98	98	100
<20 mm	5	2	0	0
≥20 and <50 mm	2	0	2	0
Systemic reactions
Fever2
None	92	93	96	93
Mild	7	5	2	7
Moderate	2	2	2	0
Malaise2
None	68	60	84	74
Mild	23	27	4	15
Moderate	8	13	12	11
Myalgia
None	80	87	94	89
Mild	12	10	4	7
Moderate	7	3	2	4
Severe	2	0	0	0
Nausea2
None	83	80	96	93
Mild	12	15	0	7
Moderate	5	5	4	0
Headache
None	72	70	78	80
Mild	23	27	16	20
Moderate	5	3	4	0
Severe	0	0	2	0
Oral temperature2
<37.8°C	100	98	98	100
≥37.8°C and <38°C	0	2	0	0
≥38°C and <39°C	0	0	2	0

NOTE. ¹No severe local reactions were reported.

²No severe reactions were reported.