Table 2.
Top categories of general molecular types
| General molecular function | Number of genes | Examples |
|---|---|---|
| LOH genes | ||
| Enzyme | 80 | USP26, INPP5K, PTPRS, MAT2B |
| Kinase | 25 | CDK7, DGKE, MAP2K4, PDGFRL |
| Transporter | 21 | ATP2B3, SLC36A3, SIL1, ABCA7 |
| Transcription regulator | 20 | BRCA1, FOXD4, SOX5, VEZF1 |
| G-protein coupled receptor | 19 | GPR174, OR1A2, TAS2R7, GRM6 |
| Transmembrane receptor | 9 | SEMA5A, IL31RA, ITGB3, OSMR |
| Cytokine | 7 | IL3, ERBB2IP, EDA, CXCL16 |
| Ion channel | 6 | CCT8L2, CNGA2, GABRA6, GRIN3B |
| ASE genes | ||
| Enzyme | 18 | MGMT, PLCH1, GUCY1A3, PYGL |
| Transcription regulator | 7 | CTBP2, SMARCA4, BCLAF1, SPEN |
| Kinase | 6 | FGFR2, FGFR4, IP6K2, TAOK1 |
| Transporter | 5 | SLC44A5, SLC25A5, SNX15, LBP |
| Transmembrane receptor | 3 | HLA-DQA1, HLA-A, TNFRSF10D |
| G-protein coupled receptor | 2 | ADORA1, GPR107 |
Genes are binned exclusively into each category based on their primary molecular function terms. LOH, loss of heterozygosity; ASE, allele-specific expression.