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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Biochim Biophys Acta. 2011 Jun 23;1808(10):2337–2342. doi: 10.1016/j.bbamem.2011.06.012

Fig. 8.

Fig. 8

A possible schematic model for the aggregation of hIAPP in the presence of lipid membranes. (A) hIAPP initially binds to the membrane in a helical conformation. (B) Once bound to the membrane, hIAPP aggregates on the membrane surface to form helical bundles (C) Aggregation of the peptide causes a conformational change in the less structured C-terminus to the β-sheet conformation of the amyloid form. (D) Formation of β-sheets at the C-terminus triggers a corresponding conformational change at the N-terminus, producing the final amyloid fiber.