Table 3.

Regional atrophy associated with decline in VO₂ peak in AD (A) and with baseline (B) and decline (C) in VO₂ peak nondemented participants.

A) Decline in VO₂ peak, AD group
	k	T	Z	x	y	z
Left insula	191	4.35	3.65	−39	−10	0
Left fusiform/parahippocampal gyrus^**	235	4.72	3.88	−35	−13	−30
Left lingual gyrus	176	4.34	3.65	−28	−61	−4
Left middle occipital cortex	153	5.32	4.22	−25	−82	−2
Right caudate	109	3.82	3.31	23	4	20
Right insula	327	4.24	3.58	30	−24	15
Right occipital cortex	101	4.50	3.75	33	−64	−2
Right inferior temporal gyrus	476	4.55	3.78	60	−32	−21
B) Baseline VO₂ peak, nondemented group
Left inferior temporal cortex	332	3.90	3.58	−69	−25	−20
Left middle occipital	345	3.67	3.39	−49	−84	10
Left superior occipital cortex	480	4.14	3.76	−34	−86	23
Right uncus	160	4.31	3.89	20	14	−33
Right middle temporal pole	with above	3.63	3.36	21	12	−43
Right middle occipital	309	3.75	3.46	49	−81	−19
C) Decline in VO₂ peak, nondemented group
Left inferior frontal gyrus	227	4.71	4.18	−48	20	6
Left middle frontal	128	3.88	3.56	−25	47	−13
Left putamen	319	3.91	3.59	−20	15	−7
Right caudate	138	3.83	3.52	14	27	5

Regions are listed left to right. X, Y and Z coordinates coincide with the MNI brain atlas. A minimum cluster size (k= 100) was set as a threshold for uncorrected analyses.

^**

Region is significant with Small Volume Analysis in the Medial Temporal Lobe with Family-wise Error correction (p<0.05)