Table 2.

Associations between Patient Characteristics and Survival:

Characteristic	Hazard Ratio (95% CI)	p-value
Univariable Association
Histology: GBM vs. other	3.28 (1.50–7.17)	0.003
Biopsy vs. Craniotomy	2.22 (1.31–3.78)	0.003
CD4 count at baseline: <500 vs. ≥500*	2.07 (1.32–3.24)	0.002
CD4 count at 2 months: <200 vs. 200*	1.99 (1.27–3.11)	0.003
KPS: 60–70 vs. 80–100	1.95 (0.78–4.87)	0.15
Age: ≥55 vs. <55	1.73 (1.08–2.77)	0.02
Anticonvulsant Use : yes vs. no	1.47 (0.85–2.54)	0.17
Steroids Use: yes vs. no	1.09 (0.60–1.98)	0.78
Infection **	1.04 (0.07–1.61)	0.86
Multivariable Association
Histology: GBM vs. other	3.39 (1.43–8.02)	0.006
KPS: 60–70 vs. 80–100	3.18 (1.18–8.56)	0.022
Biopsy vs. Craniotomy	2.30 (1.31–4.04)	0.004
CD4 count at 2 months: <200 vs. 200*	1.66 (1.05–2.64)	0.03
Age: ≥55 vs. <55	1.37 (0.83–2.28)	0.22
Infection**	1.16 (0.73–1.83)	0.53

^*CD4 count at baseline is dichotomized at 500 (normal vs abnormal). CD4 count at 2 months is dichotomized at 200

^**Time dependent covariate (time-to-first-infection)