Figure 2. Transformation functions between Cu-ATSM uptake, FMISO uptake, and tissue oxygen tension.
The modeled Cu-ATSM uptake to PO2 transformation (a) and FMISO uptake to PO2 transformation (b) are in good agreement with preclinical measurements [18,28] within single deviation confidence intervals. The resulting FMISO SUV relationship to Cu-ATSM SUV (c) is a non-linear sigmoid function. Uncertainties in some measurements are within displayed markers.