Table 1. List of model parameters relating Cu-ATSM and FMISO uptake to tissue oxygen partial pressure.

All reduction potentials have been converted relative to the standard hydrogen electrode potential. Parenthetical ranges represent single deviation confidence intervals.

Symbol	Parameter	Value	Reference
ÃCuATSM	[61Cu]Cu-ATSM Molar Specific Activity	237 MBq-μmol−1	[24]
ÃFMISO	[18F]FMISO Molar Specific Activity	75.0 (50.0–100.0) GBq-μmol−1	[25]
R	Gas Constant	8.31 J-mol−1-K−1	[27]
T	Cellular Temperature	310 K	[31]
F	Faraday Constant	96.5 kJ-mol−1-V−1	[27]
$E_{\mathit{NADH}}^0$	SRPa: NAD(P)H → NAD(P)+ + H+, ne = 2	−0.320 V	[16]
$E_{CR,\mathit{FAD}}^0$	SRP: Cytochrome Reductase FAD Cofactor, ne = 1	−0.168 V	[32]
$E_{CR,\mathit{FMN}}^0$	SRP: Cytochrome Reductase FMN Cofactor, ne = 1	−0.333 V	[32]
$E_{Cu\mathit{ATSM}}^0$	SRP: CuIIATSM → CuIATSM−, ne = 1	−0.328 V	[16]
$E_{\mathit{FMISO}}^0$	SRP: RNO2 → RNO2−, ne = 1	−0.389 V	[12]
$E_{NR}^0$	SRP: Complex I Nitroreductase, ne = 1	−0.250 V	[33]
$E_{O_2}^0$	SRP: O2 → O2−, ne = 1	−0.330 V	[34]
$\mathrm{\Delta }{G}_{O_2-Cu}^0$	Free Energy Change: CuIATSM− + O2 → CuII ATSM + O2−	−22.8 kJ-mol−1	[17]
$\mathrm{\Delta }{G}_{pH}^0$	Free Energy Change: CuIATSM− + H3O+ → CuIHATSM + H2O	−17.1 kJ-mol−1	[30]
pH	Intracellular acidity in human squamous cell carcinomas	7.20 (7.10–7.30)	[35]
[H2O]	Cellular water molar concentration	55.3 mol-L−1	[31]
KCR	LECb: Cu-ATSM reduction	−5.11	Calculated
pKpH	LEC: Cu-ATSM protonation	2.88	Calculated
pKO2-Cu	LEC: Cu-ATSM reoxidation	9.62	Calculated
pKNR	LEC: FMISO reduction	−1.12	Calculated
pKO2-F	LEC: FMISO reoxidation	0.960	Calculated
KH	Henry Coefficient for O2 dissolved in H2O at 310 K	959 L-atm-mol−1	Calculated

^aSRP – standard reduction potential

^bLEC – log equilibrium constant