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DKO female mice (n = 10) develop significant proteinuria at the age of 38 to 42 weeks, compared with ApoE−/− females (n = 6) at the age of 43 weeks. Mice were housed individually in metabolic cages, and a 24-hour urine sample was assayed for albumin/creatinine ratio. Data are given as the mean ± SEM of urinary albumin/creatinine ratios.
