A: Chimeric CD4 T cells in the spleens of recipient animals (n = 12) had altered cytokine production profiles, compared with the original donor T cells before adoptive transfers (n = 5). There were no evident differences in chimeric T-cell cytokine productions among the two subpopulations of recipients (PBMNC versus PBMNC + HAG), and both groups are combined here. P values for intergroup comparisons of each parameter measured are indicated next to brackets. B: T-cell antigen receptor variable β-chain (TCRBV) expression repertoires of chimeric T cells were highly altered, compared with the original donor lymphocytes, as illustrated here by CD4 T-cell TCRBV expression profiles. *P = 0.036, HAG + PBMNC (n = 6) versus PBMNC only (n = 10); **P = 0.0096 , donor T cells (n = 5) versus both chimeric populations. In box plots, the lower whisker denotes the 10th percentile; the lower edge of the box, the 25th percentile; the middle line, the median; the square, the mean; the upper edge of box, the 75th percentile; and the upper whisker, 90th percentile.