Figure 3.

A: Proliferative responses of recipient T cells to allogeneic donor-strain target cells were greatest among those animals that had been previously exposed to the particular alloantigens of the heterotopic airway grafts (HAG). Numbers within parentheses denote number of subjects. *P = 0.02 for the intergroup comparison between HAG + PBMNC versus both other groups. cpm, counts per minute. B: Most heterotopic airway grafts (HAG) from recipient animals that did not also receive peripheral blood mononuclear cells (PBMNC) maintained normal histological appearance. In contrast, HAG among animals with concurrent adoptive transfers of PBMNC allogeneic to the HAG developed severe histological abnormalities. The latter were scored irrespective of whether or not successful T-cell engraftment occurred. Heavy horizontal line indicates mean. *P = 0.003.