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. 2011 Sep;179(3):1081–1087. doi: 10.1016/j.ajpath.2011.05.017

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© 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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Claudin-4 levels and clinical lung injury scores (LIS). A: Representative sections from two donor lungs with minimal physiological impairment (LIS < 1) demonstrating high claudin-4 staining (left panel) as compared with sections from two donor lungs with more severe physiological impairment (LIS ≥ 1) and low claudin-4 staining (right panel). Isotype controls shown for comparison. Scale bars = 100 μm. B: Distal tissue sections from donor lungs with minimal physiological impairment had significantly higher claudin-4 scores (median 34, 25^th to 75^th percentile = 23 to 56; n = 11) than donor lungs with more severe physiological impairment (median 5, 25^th to 75^th percentile = 3 to 16; n = 9) (P = 0.006). C: There was no difference in ZO-1 scores between samples with LIS < 1 and LIS ≥ 1.