Figure 10.

Renal injury in WT and IL-12p35^−/− mice on day 21 of GN. Renal injury was diminished by the lack of IL-12(p35), as shown by significantly decreased glomerular crescent formation (A) and serum creatinine levels (C), as well as a trend toward reduced proteinuria (B). D–G: Representative photomicrographs of glomerular injury (assessed on Bouin's-fixed paraffin-embedded periodic acid Schiff–stained kidney sections) on day 21, showing severe crescent formation in WT mice (D and F) and reduced disease in IL-12(p35)^−/− animals (E and G). Original magnification: ×200 (D and E); ×400 (F and G). *P < 0.05, **P < 0.01.