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The effect of IL-12(p35) deficiency on Th1, Th2, and Th17 responses. Compared with WT animals, IL-12p35−/− mice had decreased IFN-γ (A) but increased IL-4 (B) production by antigen-challenged splenocytes, resulting in a diminished IFN-γ/IL-4 ratio (C). IL-17A (D) production was up-regulated by the lack of IL-12(p35).
