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. 2011 Sep;179(3):1188–1198. doi: 10.1016/j.ajpath.2011.05.039

Figure 7.

Figure 7

The development of GN in WT and IL-23p19−/− mice on day 21. Renal injury was enhanced by IL-23(p19) deficiency, as shown by significantly increased glomerular crescent formation (A) and a trend toward augmented proteinuria (B). C: Glomerular accumulation of CD4+ T cells and neutrophils was not affected, whereas macrophage infiltration was enhanced by the lack of IL-23(p19). D–G Representative photomicrographs of glomerular injury (assessed on Bouin's-fixed paraffin-embedded periodic acid Schiff–stained kidney sections) on day 21, showing severe crescent formation in WT mice (D and F) and enhanced disease in IL-23(p19)−/− animals (E and G). Original magnification: ×200 (D and E); ×400 (F and G). gcs, glomerular cross section; Mϕ, macrophages. *P < 0.01, **P < 0.001.