Figure 2.

Progression of fibrillar and oligomeric Aβ burden in the temporal neocortex (see also Table 4). A and C: Only the AD subset is shown (open circles, n = 40). B and D: The highly selected subset of controls without dementia and with dense-core plaques is also included, with a disease duration of 0 years (dark gray circles, n = 6). In A and B, a small increase in the number of dense-core plaques was only detectable during the first years after the onset of cognitive symptoms. In C and D, the number of NAB61-positive oligomeric Aβ-enriched plaques remained unchanged after symptom onset.