Table 1.
Demographic Characteristics of the Cohorts without Dementia and with AD and Their Corresponding Subsets Included in the Quantitative Neuropathological Study
| Characteristics | Control cohort (n = 15) | AD cohort (n = 91) | P value | Control subset (n = 6) | AD subset (n = 40) | P value |
|---|---|---|---|---|---|---|
| Age at death (years)⁎ | 79.9 ± 13.3 | 79.0 ± 7.8 | NS | 83.7 ± 14.0 | 77.6 ± 8.6 | 0.0429 |
| Female sex† | 10 (66.7) | 58 (63.7) | NS | 4 (66.7) | 26 (65.0) | NS |
| Disease duration (years)‡ | NA | 9.8 (6.8–13.7) | NA | NA | 9.9 (5.4–15.5) | NA |
| APOE genotype† | ||||||
| APOEε4 carriers | 4 (26.7) | 59 (64.8) | 0.0090 | 2 (33.3) | 21 (52.5) | NS |
| APOEε4 alleles§ | 4 (13.3) | 70 (38.5) | 0.0070 | 2 (16.7) | 25 (31.2) | NS |
| Post-mortem interval (hours)⁎ | 22.3 ± 12.8 | 13.9 ± 9.1 | 0.0085 | 21.0 ± 11.1 | 14.1 ± 6.2 | NS |
Information about cause of death was available in only 44 of the 91 subjects with AD because nursing homes are the main source of our brain donation program. Patients with protracted death (mostly aspirative pneumonia and cancer, n = 31) did not differ from patients with sudden death (mostly pulmonary emboli and myocardial infarction, n = 13) regarding their age at death (P = 0.2261), disease duration (P = 0.9898), or amount of astrocytosis (P = 0.1870) and microgliosis (P = 0.9180). Statistically significant P values are boldfaced.
NA, not applicable; NS, not significant.
Data are given as mean ± SD. P values were obtained using the two-tailed Mann-Whitney U-test.
Data are given as number (percentage) of each group. P values were obtained using the two-tailed χ2 test with Fisher's exact test.
Data are given as median (interquartile range).
To obtain percentages, the denominators for this row were doubled.