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Epithelial–mesenchymal transition contributed to the tumorigenic activity of iC3-1 cells. A: Morphology of HTR8/SVneo/EGFP (upper) and iC3-1 (lower) (left, ×40 magnification: right, ×100 magnification). B: Quantitative RT-PCR analysis of EMT-related genes in iC3-1 compared with HTR8/SVneo/EGFP (*P < 0.05). C: Immunohistochemical staining of E-CADHERIN (left, ×600 magnification) and VIMENTIN (right, ×600 magnification) in iC3-1–derived tumors.
