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. 2011 Sep;179(3):1338–1346. doi: 10.1016/j.ajpath.2011.05.023

Figure 6.

Figure 6

Average modified Mankin scores of the TRE-DDR2 and Comp-tTA;TRE-DDR2 mice after DMM and their wild-type littermates after sham surgery. The morphologic conditions of the articular cartilages from the knee joints were evaluated. An average score representing six to eight animals from each experimental group was obtained. A statistical comparison of the scores using the Mann–Whitney U test indicated a significant difference among the groups at each age. *P < 0.01. Wild-type mice at 2 weeks after sham surgery served as control, score 0. At 2 weeks after DMM surgery, scores for the Comp-tTA;TRE-DDR2 mice, TRE-DDR2 mice, and their wild-type littermates were 1.4, 0.6, and 0.5, respectively. At 4 weeks after surgery, scores were 2.7 for the Comp-tTA;TRE-DDR2 mice, 1.9 for TRE-DDR2 mice, 2.4 for the wild-type littermates, and 0.5 for the sham surgery mice. At 8 weeks after surgery, scores were 4.3 for the Comp-tTA;TRE-DDR2 mice, 2.8 for TRE-DDR2 mice, 2.7 for the wild-type littermates, and 0.5 for the sham surgery mice. At 12 weeks after surgery, scores were 6.6 for the Comp-tTA;TRE-DDR2 mice, 5.3 for TRE-DDR2 mice, 5.6 for their wild-type littermates, and 0.7 for the sham surgery mice. We found the degenerative progression of the Comp-tTA;TRE-DDR2 mice to be accelerated, particularly at 4 weeks after DMM surgery.