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. 2011 Aug;179(2):915–930. doi: 10.1016/j.ajpath.2011.04.008

Figure 8.

Figure 8

AAV2-MPRO improves skeletal muscle healing at 4 weeks after injury. A: Masson's trichrome staining shows that fibrotic tissue (blue) exists at the muscle injury site. B: Fibrosis in the AAV2-MPRO–treated injured muscles was significantly less than the untreated control. Original magnification, ×200. C: Collagen IV (green) and MPRO (red) double-immunostaining shows a strong MPRO signal in the cytoplasm of the fibers of AAV2-MPRO transduced muscle. D: AAV2-MPRO transduced GMs gained significantly more weight than the GM controls. E: H&E staining revealed muscle hypertrophy in the AAV2-MPRO–treated injured muscles. F: A significant increase in the average diameter of the regenerating myofibers was observed in the AAV2-MPRO injected muscles when compared with the controls (**P < 0.01). Original magnification, ×100. G: Frequency histograms show the distribution of regenerating myofibers in the AAV-MPRO–treated and control muscles. Scale bar = 100 μm.