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. 2011 Aug;179(2):628–638. doi: 10.1016/j.ajpath.2011.04.003

Figure 4.

Figure 4

ACE inhibitor reduces the number and extension of crescents and limits progenitor cell activation. A: A significant decrease in proteinuria levels and index of crescents was observed in 60-week-old (60w) MWF rats receiving ACEi for 10 weeks as compared with animals given saline. *P < 0.01 versus 60w MWF. B: The percentage of proliferating claudin1+WT1− cells (white bars), claudin1+WT1+ cells (gray bars), and claudin1−WT1+ cells (black bars) was lower in crescents of ACEi-treated MWF rats with respect to animals given saline. Cell proliferation was assessed by quantification of the number of BrdU+ cells in pulse-chased MWF rats. **P < 0.05 versus 60w MWF; *P < 0.01 versus 60w MWF. C: The expression of NCAM, which identifies renal progenitor cells, was evaluated in crescentic lesions of 60-week-old MWF rats. Note that NCAM+ cells (red) were localized in Bowman's capsule and capillary tuft, as well as in crescents. D: ACEi effectively reduced the presence of progenitor cells in crescents and restored the distribution of NCAM+ cells in the Bowman's capsule to the pattern observed in controls (shown in Figure 1). Nuclei are stained with DAPI (blue). Original magnification, ×630.