Figure 2.

The PPIN analysis was performed for 556 proteins matched with 1193 differentially expressed brain metastasis genes (transcriptomic comparison of brain metastases versus other metastases), yielding 37 pairs corresponding to 7 underexpressed and 30 overexpressed organ-specific proteins. FatiGO, an online tool for finding significant associations of gene ontology-terms with groups of genes,²⁴ shows the preponderant functions of significant proteins in clusters of coexpression. The classification by function was performed using GO level 6.