The area under the ROC curve (AUC) obtained with the integrated predictive indexes. Markers were assessed in a multivariate logistic regression model using a forward stepwise procedure to identify the best combination to predict brain metastasis. For ErbB-2 alone, AUC = 0.76; for GRP94, FN14, and inhibin in combination, AUC = 0.85; and for ErbB-2, GRP94, FN14, and inhibin in combination, AUC = 0.91.