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. 2011 Aug;179(2):1050–1060. doi: 10.1016/j.ajpath.2011.05.006

Figure 3.

Figure 3

Tumor development in Cygb-deficient mice treated with 0.05-ppm DEN for 36 weeks. A: Tumor incidence in total, livers, and lungs from 0.05-ppm DEN-treated Cygb+/+ (white bars), Cygb+/− (gray bars), and Cygb−/− (black bars) mice (n = 7 to 15). *P < 0.05, **P < 0.01 compared with the wild type. B: Gross photographs of livers (top) from Cygb+/+ and Cygb−/− mice treated with 0.05-ppm DEN, as previously mentioned; arrows indicate lung tumors. Representative photomicrographs of H&E-stained paraffin sections of liver parenchyma (bottom) from wild-type and moderately differentiated hepatocellular carcinoma composed of large cells that vary in size and shape (arrows), from Cygb−/− mice. Scale bar = 100 μm. C: Representative photomicrographs of H&E-stained paraffin sections of lungs from Cygb+/+, Cygb+/−, and Cygb−/− mice treated with 0.05-ppm DEN for 36 weeks. Scale bars: 400 μm (top); 100 μm (bottom). Arrows indicate lung tumors that were classified as adenocarcinomas. No lung tumor was observed in Cygb+/+ mice.