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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Hypertension. 2010 Aug 16;56(4):705–712. doi: 10.1161/HYPERTENSIONAHA.110.154880

Figure 1. Normalization of BP in IEX-1 KO mice by anti-oxidant treatment.

Figure 1

A. Increased SBP in 12-wk-old but not in 4-wk-old mice. SBP was measured noninvasively in awake IEX-1 KO (filled) and age-matched WT (blank) mice at the indicated age. B. NAC completely prevents hypertension. IEX-1 KO and WT mice at 3 wks of age were given NAC (10 g/L) or vehicle (veh) with drinking water for 15 wks. NAC or vehicle was later omitted from the drinking water (arrow) and SBP was measured again after two wks of treatment. C and D. Reduction of SBP in IEX-1 KO mice by MnTBAP but not by NADPH oxidase inhibitor apocynin. IEX-1 KO and WT mice at 12 wks of age were daily given 5 mg MnTBAP/kg/d or vehicle control by intraperitoneal injection (C), or fed 1.5 mmol/L apocynin (Apo) or vehicle in drinking water for two wks (D). As a positive control for the efficacy of apocynin, WT mice were infused with angiotensin II (Ang II) at a dose of 0.7mg/kg/d via an implanted osmotic minipump, with or without apocynin in their drinking water for two wks. Data are expressed as mean ± SEM of SBP (mmHg); n = 6 in A and B and 5 in C and D. ** p<0.01 and ***p<0.001 with or without treatment or in the presence or absence of IEX-1.