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. 2011 Aug;179(2):1041–1049. doi: 10.1016/j.ajpath.2011.04.027

Figure 3.

Figure 3

Podoplanin regulates cell migration in OS cell lines. A: Stable transfectants (PDPN-11, -14, and -17) or mock transfectants were seeded into transwell chambers and incubated for 18 hours in serum-free medium. The number of migrated cells was determined by counting stained cells in the lower well. *P < 0.001 compared to mock transfectants by analysis of variance with the Tukey-Kramer test. B: U-2 OS cells were incubated with a control IgG (Co IgG) or an anti-podoplanin antibody (PDPN Ab) for 15 minutes before seeding into a transwell chamber as above. Data are means ± SEM of triplicate determinations. **P = 0.0022 by the Mann-Whitney U-test.