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. 2011 Sep;179(3):1385–1393. doi: 10.1016/j.ajpath.2011.05.018

Figure 2.

Figure 2

β-hCG expression promotes cell cycle progression and up-regulation of cyclins and associated cyclin-dependent kinases in immortalized ovarian surface epithelial cells. A: Flow cytometry analysis of cell cycle progression revealed decreased G1 cell populations in T29 β-hCG cells (48.8% versus 39.5%) and T80 β-hCG cells (52.5% versus 43.1%), as well as increased G2-phase in T29 β-hCG cells (22.6% versus 33.2%) and T80 β-hCG cells (19.7% versus 29.8%), relative to T29 or T80 parental control cells. B: Up-regulation of cyclins E and D1, as well as of Cdk2, Cdk4, and Cdk6, was demonstrated in T29 β-hCG and T80 β-hCG cells, relative to parental control cells.