Figure 5.

Effect of temsirolimus on deep infiltrating endometriotic tissue in a mouse model. A: Pathology scores were calculated on day 21 on untreated and treated mice: *P < 0.01. B: Histological views of deep infiltrating implant on day 21 in untreated mice (left) and in treated mice (right). In untreated mice, the appearance of the implanted deep infiltrating endometriotic tissue was typical, with endometriotic glands (black arrow) and with stroma (white arrow) surrounded by fibrosis and hyperplastic smooth muscle fibers (dotted black arrow). By contrast, treated mice (right) displayed fibrotic and avascular lesions (black arrow) with hemosiderin (white arrow).