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. 2011 Sep;179(3):1434–1442. doi: 10.1016/j.ajpath.2011.05.040

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© 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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CCL18 is expressed in lesional MF skin. A: Immunofluorescence staining revealed that CCL18 protein (green) was significantly expressed in lesional skin of MF patch or plaque and MF tumor stage but not in healthy skin. CCL18 was predominately expressed at the invasive margin of the CD4⁺ (red) cellular tumor infiltrate (tumor-stroma interface). B: CCL18 (green) can be expressed in the epidermis close to Pautrier's microabscesses indicated by CD3 (red) staining in the epidermis (original magnification, ×400). C: CCL17 (green) was expressed amid tumor cells (CD4, red) and the dermal area around tumor cells. D: Immunofluorescence staining also detected CCL18 in PEP lesions.