The tumorigenicity of U87 GBM cells after knockdown Anx A1. A: The tumorigenicity of U87 GBM cells containing Anx A1 or FPR1 siRNA. After s.c. injection of U87 GBM, Anx KD, FPR1 KD, and Double KD U87 GBM cells into nude mice, tumor volume was measured at different time points. *P < 0.01, compared with tumors formed by U87 GBM cells. Data are mean ± SEM. B: The survival curves of mice bearing tumors formed by U87 GBM cells containing siRNAs targeting Anx A1, FPR1, and both. *P < 0.01, compared with mice bearing tumors formed by U87 GBM cells. Data (A and B) are representative of results from two independent experiments with three to five mice in each group.