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. 2011 Sep;179(3):1095–1103. doi: 10.1016/j.ajpath.2011.05.045

Figure 1.

Figure 1

Detection of diffuse and fibrillar Aβ deposits by anti-Aβ antibody and thioflavin S and quantification of buffer-extractable and buffer-unextractable Aβ by ELISA in APP MyD88−/− and APP mice. Aβ deposits in the brain are visualized by immunohistochemical staining using 6E10 antibody in APP MyD88−/− (A) and APP (C) mice. Percentages of areas showing Aβ immunoreactivity measured by morphometry in the hippocampus and neocortex (E) are shown. Fibrillar Aβ deposits in the brain are visualized by thioflavin S fluorescence in APP MyD88−/− (B) and APP (D) mice. Percentages of areas showing fluorescence measured by morphometry in the hippocampus and neocortex (F) are shown. In the neocortex and hippocampus, the Aβ load in APP MyD88−/− mice is significantly less than that in APP mice. Quantification of buffer-extractable (G) and buffer-unextractable (H) Aβ in the cerebrum of APP MyD88−/− and APP mice at 10 months of age. Levels of buffer-extractable and buffer-unextractable Aβ40 and Aβ42 were determined by ELISA. The data shown are the mean ± SEM of n = 6 for each group (E–H). **P < 0.05, ***P < 0.01, ****P < 0.001. Scale bars = 1 mm.

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