Table 1.
Percentages of sequence identity between the aligned sequences of the hP2Y12R and the available structural templates.
| hP2Y12R | bRHO, % | tADRB1, % | hADRB2, % | hA2AAR, % | hCXCR4, % | hDRD3, % |
|---|---|---|---|---|---|---|
| overall | 15.9 | 17.5 | 17.6 | 15.5 | 21.9 | 18.2 |
| TMs | 18.8 | 23.2 | 20.8 | 19.3 | 25.6 | 23.2 |
| TM1 | 16.7 | 13.3 | 10.0 | 6.7 | 23.3 | 23.3 |
| TM2 | 20.0 | 16.7 | 16.7 | 6.7 | 20.0 | 10.0 |
| TM3 | 18.2 | 33.3 | 33.3 | 27.3 | 33.3 | 30.4 |
| TM4 | 12.0 | 24.0 | 16.0 | 24.0 | 26.0 | 16.0 |
| TM5 | 21.2 | 21.2 | 18.2 | 15.2 | 18.2 | 24.2 |
| TM6 | 25.0 | 28.1 | 25.0 | 18.8 | 21.9 | 28.1 |
| TM7 | 16.7 | 25.0 | 25.0 | 25.0 | 29.0 | 33.3 |
| EL3-TM7 | 10.3 | 15.4 | 15.4 | 20.5 | 27.5 | 23.1 |
hP2Y12R = human P2Y12 receptor; bRHO = bovine rhodopsin; tADRB1 = turkey β1 adrenergic receptor; hADRB2 = human β2 adrenergic receptor; hA2AAR = human A2A adenosine receptor; hCXCR4 = human C-X-C chemokine type 4 receptor; hDRD3 = human dopamine type 3 receptor. The residues considered for the TM segments: from 1.30 to 1.59 for TM1; from 2.38 to 2.67 for TM2; from 3.33 to 3.55 for TM3; from 4.39 to 4.63 for TM4; from 5.36 to 5.68 for TM5; from 6.29 to 6.60 for TM6; from 7.32 to 7.55 for TM7; from 6.61 to 7.55 for EL3-TM7.