Table 2. Comparison of NS subscale score and onset age of heroin use in heroin dependent subjects with different COMT SNP genotypes.
| SNP | Genotype Mean(SD) | P | Permutation Pa | ||
| rs737866 | T/T(n = 221) | C/T(n = 218) | C/C(n = 39) | ||
| NS | 57.2 (6.8) | 55.5 (7.5) | 54.5 (7.4) | 0.004 | 0.005 |
| Onset age | 21.9 (5.5) | 24.0(6.4) | 22.3 (6.3) | 0.014 | 0.019 |
| rs933271 | T/T(n = 182) | T/C(n = 214) | C/C(n = 82) | ||
| NS | 55.6 (7.9) | 56.5 (6.5) | 56.9 (7.3) | 0.109 | 0.131 |
| Onset age | 23.0(6.2) | 23.1(6.3) | 21.9(5.4) | 0.291 | 0.311 |
| rs1544325 | G/G(n = 224) | A/G(n = 191) | A/A(n = 43) | ||
| NS | 56.1 (6.9) | 56.2 (7.4) | 56.7 (7.6) | 0.664 | 0.857 |
| Onset age | 23.0 (6.2) | 22.9 (6.0) | 22.1 (6.0) | 0.427 | 0.429 |
| rs599250 | C/C(n = 409) | C/T(n = 69) | T/T(n = 0) | ||
| NS | 56.3 (7.2) | 55.8 (7.0) | — | 0.606 | 0.563 |
| Onset age | 23.2(6.2) | 21.3(5.20) | — | 0.018 | 0.022 |
| rs4818 | C/C(n = 204) | C/G(n = 213) | G/G(n = 61) | ||
| NS | 57.3 (6.9) | 55.3 (7.4) | 55.4(6.8) | 0.01 | 0.012 |
| Onset age | 22.3 (5.9) | 23.5 (6.4) | 22.4(5.4) | 0.336 | 0.458 |
| rs4680 | G/G(n = 244) | A/G(n = 207) | A/A(n = 27) | ||
| NS | 55.8 (7.1) | 56.7 (7.3) | 56.1 (7.5) | 0.287 | 0.298 |
| Onset age | 22.9 (5.9) | 22.8(6.4) | 22.6(6.1) | 0.776 | 0.857 |
| rs174696 | C/C(n = 131) | C/T(n = 239) | T/T(n = 108) | ||
| NS | 57.7 (7.1) | 55.7 (7.2) | 55.5 (7.2) | 0.015 | 0.017 |
| Onset age | 22.7 (5.9) | 23.3 (6.2) | 22.3 (6.0) | 0.727 | 1 |
| rs174699 | C/C(n = 165) | T/C(n = 222) | T/T(n = 91) | ||
| NS | 56.5 (7.2) | 56.1(7.0) | 55.9 (7.7) | 0.497 | 0.7 |
| Onset age | 23.8 (6.5) | 22.4(6.1) | 22.5(5.1) | 0.047 | 0.085 |
a
Correction for multiple testing was performed using permutation test based on 100 000 permutations.