Table 3. Haplotype Analysis of COMT SNPs with NS subscale score and onset age of heroin use in heroin dependent subjects.

Haplotype		Novelty Seeking subscale score				Onset age of heroin use
	F	Beta	Stat	P	Permutation Pa	Beta	Stat	P	Permutation Pa
rs737866-rs933271
TC	0.388	0.854	3.36	0.067	0.067	−0.56	2.01	0.157	0.162
CT	0.302	−1.38	7	0.006	0.008	0.926	4.39	0.034	0.037
TT	0.303	0.387	0.597	0.44	0.44	−0.359	0.715	0.398	0.407
rs174696-rs174699-rs4680
TTA	0.101	0.327	0.137	0.711	0.717	−0.384	0.266	0.606	0.603
CTA	0.132	1.28	2.58	0.11	0.109	0.398	0.349	0.555	0.562
TCG	0.121	−0.899	1.41	0.236	0.247	−1.12	3.04	0.082	0.086
CCG	0.262	0.192	0.111	0.74	0.733	−0.38	0.606	0.437	0.438
TTG	0.229	−1.38	5.52	0.02	0.019	0.988	3.94	0.048	0.05
CTG	0.115	2.04	6.19	0.013	0.014	0.467	0.449	0.503	0.501

^aCorrection for multiple testing was performed using permutation test based on 10 000 permutations.