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. 2011 Aug 17;6(8):e22566. doi: 10.1371/journal.pone.0022566

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Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. Observation of tumors in the large bowel of mice after sacrifice at 24 weeks. B (×200) and C (×400). Most of the tumors were confirmed as adenocarcinomas by pathological examination. D. Tumor incidence among the 4 groups. E. Tumor number/mice among the 4 groups. F. Maximum tumor diameter among the 4 groups (Control: Control group, received normal feed and injection of normal sodium for 20 weeks; DMH: DMH group, received normal feed and injection of DMH for 20 weeks; DMH+Calcium group: received high-calcium feed and injection of DMH for 20 weeks; Calcium group: received high-calcium feed and injection of normal sodium for 20 weeks). * P value<0.05 between DMH+Calcium group and DMH group.