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. 2011 Aug 17;6(8):e23449. doi: 10.1371/journal.pone.0023449

Figure 7. Distribution of sonic hedgehog (Shh), patched-1 (Ptc), smoothened (Smo) and Gli-2 across ages.

Figure 7

The levels of Shh, its receptor Ptc and its downstream effectors were seen to decrease in preterms with maximum ex-utero exposure, in comparison to their age matched controls. Compare 37 wk (I–L) with 35 wk+17 d (M–P) and 39 wk (Q–T) with 34 wk+36 d (U–X); Abbreviations used - wk = number of gestational weeks, d = number of postnatal days. EGL = external granular layer, ml = molecular layer, PL = purkinje cell layer, IGL = internal granular layer. Sections were stained by immunofluorescence for Shh, while Ptc, Smo and Gli-2 reactivity were developed using the peroxidase method. Scale bar = 50 µm.