Table 1. Demographic data and summary of expansion fold and transduction efficiency.
CD4T-1 | CD4T-2 | CD4T-3 | |
Body Weight (kg) | 5.25 | 5.18 | 3.7 |
Method for stimulation | Con A | Anti-CD3/CD28 Beads | Anti-CD3/CD28 Beads |
Number of stimulated CD4+ T cells (×107 cells) | 13.0 | 1.0 | 4.6 |
Days for expansion (days) | 7 | 7 | 9 |
Number of infused MazF-Tmac cells (×109 cells) | 1.6 | 1.7 | 2.7 |
Expansion Fold | 12.3 | 170 | 58.7 |
Gene transfer efficiency (%) | 34.5 | 61.8 | 60.0 |